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Testostérone cyclisme
-- Alternatives légales et sûres, testostérone cyclisme. Although speculative at this point, it is possible that dissociated GR ligands will become useful in the future to prevent loss of muscle mass in conditions characterized by glucocorticoid-regulated muscle wasting and in patients being treated with glucocorticoids. The action of glucocorticoids in peripheral tissues is regulated by the enzymes 11β-HSD1 and 11β-HSD2 that convert inactive to active corticosteroid and active to inactive corticosteroid, respectively [48]. In order to reduce tissue levels of active glucocorticoids, several new classes of 11β-HSD1 inhibitors are presently being developed [reviewed in ref #35*]. Although these drugs have been tested mainly in the context of glucocorticoid-regulated insulin resistance and treatment of diabetes, it may be speculated that they will become useful in the treatment of glucocorticoid-induced muscle wasting as well. Interestingly, in a recent study, treatment of cultured C2C12 myotubes with retinoic acid, the carboxylic form of vitamin A, resulted in downregulated expression and activity of 11β-HSD1 and made the myotubes resistant to the effects of glucocorticoids [49*], .
Alpha anavar
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